139347-65-2

Usage

Molecular Structure

1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-(1-methylethyl)-1-phenylis a chemical compound that contains a pyrazole ring and a carboxaldehyde functional group.

Functional Groups

The compound contains a carboxaldehyde functional group, which is a carbonyl group (C=O) attached to a hydrogen atom and a phenyl group.

Substituents

The compound has a 5-chloro-3-(1-methylethyl) and 1-phenyl substituents on the pyrazole ring, which can affect its chemical properties and reactivity.

Chlorine Atom

The presence of a chlorine atom in the compound can increase its reactivity and may have an impact on its potential applications.

Phenyl Group

The presence of a phenyl group in the compound can increase its lipophilicity and may have an impact on its biological activity.

Potential Applications

The compound may have potential applications in the development of pharmaceuticals and agrochemicals, as well as in the synthesis of heterocyclic compounds.

Safety Precautions

It is important to handle 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-(1-methylethyl)-1-phenyl- with care and follow proper safety protocols due to its potential hazards and reactivity.

Upstream product

• 64123-72-4 5-isopropyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 909250-34-6 5-(4-chloro-phenoxy)-3-isopropyl-1-phenyl-1H-pyrazole-4-carbaldehyde 
• 97112-00-0 5-Isopropyl-4-[1-methylamino-meth-(Z)-ylidene]-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97111-99-4 4-[1-Ethylamino-meth-(Z)-ylidene]-5-isopropyl-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97131-11-8 4-[1-tert-Butylamino-meth-(Z)-ylidene]-5-isopropyl-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97111-92-7 5-Isopropyl-4-[1-isopropylamino-meth-(Z)-ylidene]-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97111-98-3 4-[1-sec-Butylamino-meth-(Z)-ylidene]-5-isopropyl-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97111-96-1 4-[1-Benzylamino-meth-(Z)-ylidene]-5-isopropyl-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97112-02-2 5-Isopropyl-4-[1-(4-methoxy-phenylamino)-meth-(Z)-ylidene]-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97111-94-9 4-[1-Cyclohexylamino-meth-(Z)-ylidene]-5-isopropyl-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 97112-01-1 5-Isopropyl-4-[1-(naphthalen-1-ylamino)-meth-(Z)-ylidene]-2-phenyl-2,4-dihydro-pyrazole-3-thione 
• 139347-69-6 4-Cyano-5-hydroxy-3-isopropyl-1-phenylpyrazole 
• 861435-79-2 5-(4-chloro-phenoxy)-3-isopropyl-1-phenyl-1H-pyrazole-4-carbaldehyde oxime 
• 133885-49-1 1-phenyl-3-isopropyl-4-formyl-5-mercaptopyryzole 

Relevant academic research and scientific papers

Synthesis of Selenopyrano[2,3- c ]pyrazol-4(1 H)-ones and Their C-H Activation

We disclose the synthesis of selenopyrano[2,3- c ]pyrazol-4(1 H)-ones and their aryl derivatives for the first time by using selenopyran ring formation via an in situ-generated selenide that reacts directly with α-halo-β-ynone-bearing substituted pyrazole

A novel synthetic method of organoselenum compounds

The present application can synthesize a selenopyrano pyrazolone derivative, one of an organic selenium compound, in a simple and excellent yield. Provided is a synthesis method of an organic selenium compound which is eco-friendly at low temperature and

Identification of antitumor activity of pyrazole oxime ethers

A series of pyrazole oxime ether derivatives were prepared and examined as cytotoxic agents. In particular, 5-phenoxypyrazole was comparable to doxorubicin, while exhibiting very potent cytotoxicity against XF 498 and HCT15.

Azide Ring-Opening-Ring-Closure Reactions and Tele-substitutions in Vicinal Azidopyrazole-, Pyrrole- and Indolecarboxaldehydes

5-Chloro-1-methylpyrazole-4-carboxaldehydes 1 react with excess sodium azide in dimethyl sulfoxide to produce a mixture of 1-azidomethyl-4-cyanopyrazoles 2 and 4-cyano-5-hydroxy-1-methylpyrazoles 3.Application of this reaction to the corresponding 5-chloro-1-phenylpyrazole-4-carboxaldehydes 5 gave 4-cyano-5-hydroxy-1-phenyl-pyrazoles 7 as the sole products in high yields.Likewise, 2-aryl-5-chloro-1-methylpyrrole-3,4-dicarboxaldehydes 9 rearranged to 2-aryl-4-cyano-5-hydroxy-1-methylpyrrole-3-carboxaldehydes 10 in high yields.In the indole series, treatment of 1-aryl-2-chloroindole-3-carboxaldehydes 11 with NaN3 yielded a mixture of 1-aryl-3-cyano-2(3H)-indolones 13 and 1-aryl-5-azido-3-cyanoindoles 12, both products resulting from a ring-opening-ring-closure reaction with concomitant nucleophilic tele-substitution at the 5-position of the indole ring.