13935-97-2

Basic information

• Product Name: 1H-Indene-1,3(2H)-dione, 2-(2,6-dimethylphenyl)-
• CAS NO: 13935-97-2
• Molecular Formula: C17H14O2
• Molecular Weight: 250.297
• Mol File: 13935-97-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Indene-1,3(2H)-dione, 2-(2,6-dimethylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene-1,3(2H)-dione, 2-(2,6-dimethylphenyl)-(13935-97-2)
• EPA Substance Registry System: 1H-Indene-1,3(2H)-dione, 2-(2,6-dimethylphenyl)-(13935-97-2)

Safety Data

• Hazardous Substances Data: 13935-97-2(Hazardous Substances Data)

Usage

Classification

Indole, Ketone

Physical appearance

Yellowish color, characteristic odor

Solubility

Soluble in organic solvents such as ethanol and acetone

Uses

Precursor in the synthesis of various pharmaceuticals and other organic compounds

Biological activities

Anti-inflammatory, anti-cancer, and anti-microbial properties

Value in medicinal chemistry

Valuable compound for its various biological activities

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 1123-56-4 2,6-dimethylbenzaldehyde 

Relevant articles and documents

Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists

The androgen receptor (AR) plays important roles in multiple physiological functions, including differentiation, growth, and maintenance of male reproductive organs, and also has effects on hair and skin. In this paper, we report the synthesis of nonsteroidal AR antagonists having a 4-benzyl-1-(2H)-phthalazinone skeleton. Among the synthesized compounds, 11c with two ortho-substituents on the phenyl group potently inhibited SC-3 cell proliferation (IC50: 0.18 μM) and showed high wt AR-binding affinity (IC50: 10.9 μM), comparable to that of hydroxyflutamide (3). Compound 11c also inhibited proliferation of LNCaP cells containing T877A-mutated AR. Docking study of 11c with the AR ligand-binding domain indicated that the benzyl group is important for the antagonism. These phthalazinone derivatives may be useful for investigating potential clinical applications of AR antagonists.