1393527-63-3Relevant academic research and scientific papers
Palladium(II)-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives
Jana, Ranjan,Pathak, Tejas P.,Jensen, Katrina H.,Sigman, Matthew S.
supporting information; experimental part, p. 4074 - 4077 (2012/09/22)
A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity.
