1393580-83-0

Basic information

• Product Name: ethyl (Z)-3-(4-(4-ethoxy-3-methoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate
• Synonyms: ethyl (Z)-3-(4-(4-ethoxy-3-methoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate
• CAS NO: 1393580-83-0
• Molecular Weight: 408.454
• Mol File: 1393580-83-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (Z)-3-(4-(4-ethoxy-3-methoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (Z)-3-(4-(4-ethoxy-3-methoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate(1393580-83-0)
• EPA Substance Registry System: ethyl (Z)-3-(4-(4-ethoxy-3-methoxybenzylidene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoate(1393580-83-0)

Safety Data

• Hazardous Substances Data: 1393580-83-0(Hazardous Substances Data)

Upstream product

• 90556-87-9 3-hydrazinylbenzoic acid ethyl ester 
• 38235-71-1 3-hydrazinobenzoic acid 
• 354997-99-2 ethyl 3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-benzoate 
• 120-25-2 4-ethoxy-3-methoxybenzaldehyde 

Relevant articles and documents

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists

LBVS of 12480 in-house compounds, followed by HTRF assay, resulted in one nonsteroidal compound (11) with antagonistic activity against FXR (69.01 ± 11.75 μM). On the basis of 11, 26 new derivatives (12a-z) were designed and synthesized accordingly. Five