1393596-06-9

Upstream product

• 31162-13-7 2-azidobenzoic acid 
• 88333-03-3 Benzyl isocyanide 
• 153463-32-2 (S)-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(4-methoxyphenyl)azetidine-2,3-dione 

Downstream Products

• 1393596-42-3 C₇₄H₇₂N₁₀O₁₆ 
• 1393596-29-6 C₃₈H₃₅N₅O₇ 
• 1393596-52-5 C₁₀₂H₉₆N₁₈O₂₄ 
• 1393596-46-7 C₇₄H₇₂N₁₀O₁₆ 

Relevant academic research and scientific papers

Regio- and diastereoselective synthesis of β-lactam-triazole hybrids via passerini/CuAAC sequence

Passerini (P-3CR) and Passerini-Smiles reactions were investigated in azetidine-2,3-diones, affording the corresponding 3,3-disubstituted-β- lactams with complete diastereoselectivity in high yields. The study has been carried out using different isocyanides, carboxylic acids, and phenols showing the scope of both reactions. In addition, the regioselective synthesis of highly functionalized β-lactam-triazole hybrids has been developed via a Passerini/CuAAC sequence. Interestingly, the use of dialkynes/diazides or trialkynes/triazides as linkers in the CuAAC step has allowed the synthesis of C2 and C3 symmetric β-lactam-triazole hybrids, respectively.