1393641-46-7Relevant academic research and scientific papers
Novel synthetic route to pyrano[2,3-b]pyrrole derivatives
Damavandi, Saman,Sandaroos, Reza
experimental part, p. 621 - 627 (2012/08/08)
Synthesis of a new series of 2-amino-4,7-dihydro-4-arylpyrano[2,3-b] pyrrole-3-carbonitrile has been reported. The acid-catalyzed cyclocondensation synthesis proceeded by the one-pot reaction of 2-hydroxypyrrole, malononitrile, and various aromatic aldehydes in the presence of silica-supported ionic liquid of [pmim]HSO4 SiO2 (silica-supported 1-methyl-3- (triethoxysilylpropyl)imidazolium hydrogensulfate) as an efficient catalyst. The electronic nature of the substitution attached to the aldehyde affected the reaction efficiency profoundly.
