1393649-86-9Relevant academic research and scientific papers
Bis-(cyanoacetamide)alkanes in heterocyclic synthesis: Synthesis of bis-heteryl(carboxymido)alkanes and bis-(heteryl)alkanes of thiophene, pyrrole, thiazole and pyrimidinone series
Elneairy, Mohamed A.A.,Mekky, Ahmed E.M.,Ahmed, Ahmed A.M.
experimental part, p. 373 - 383 (2012/08/28)
Bis-N-substituted cyanoacetamides 3a and b reacted with active methylene-containing compounds 2a-c and elemental sulfur to give bis-thiophene 4a and b and bis-pyrrole 6a and b derivatives. Compounds 4a and b reacted with ethyl cyanoacetate 2a to afford bis-thienopyrimidine derivatives 5a and b; on the other hand, 6a and b reacted with cyanothioacetamide 2c to give the corresponding bis-thioxopyrrolopyrimidine derivatives 7a and b. Compounds 7a and b reacted with methyl iodide to give the corresponding bis-2-S- methylpyrrolopyrimidine derivatives 8a and b, which could be, in turn, cyclized into the bispyrazolopyrrolopyrimidine derivatives 9a and b by refluxing with hydrazine hydrate. On the other hand, 7a and b reacted with ethyl chloroacetate to yield the corresponding bis-thienopyrrolopyrimidine derivatives 10a and b. Finally, compounds 3a and b reacted with phenylisothiocyanate and elemental sulfur to give the corresponding bis-2-thioxoaminothizole derivatives 11a and b.
