139368-06-2Relevant academic research and scientific papers
Conformational analysis of 5-lipoxygenase inhibitors: Role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series
Lambert-van der Brempt,Bruneau,Lamorlette
, p. 113 - 124 (2007/10/02)
The investigation of the SAR of 5-lipoxygenase (5-LO) inhibition of a series of racemic (methoxyalkyl)thiazoles, exemplified by compound 7 (ZM- 211965), has led to other active, racemic derivatives in which the thiazole moiety has been replaced by an este
PYRAN DERIVATIVES AND THEIR USE AS INHIBITORS OF 5-LIPOXYGENASE
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, (2008/06/13)
The invention concerns a cyclic ether derivative of the formula I, wherein Ar1 is optionally substituted phenyl, naphthyl or a 9-or 10-membered bicyclic heterocyclic moiety; A1 is a direct link to X1 or (l-3C)alkylene; X1 is oxy, thio, sulphinyl, sulphony
