1393717-21-9Relevant articles and documents
Intercepted decarboxylative allylations of nitroalkanoates
Schmitt, Meghan,Grenning, Alexander J.,Tunge, Jon A.
, p. 4494 - 4497 (2012)
Using palladium-catalyzed decarboxylation, several cascade reactions of allyl and prenyl nitroalkanoates that lead to nitro-containing chemical building blocks are described. A nitronate Michael addition/Tsuji-Trost allylation cascade was developed, leading to functionally dense chemical building blocks. Likewise, a Tsuji-Trost/decarboxylative protonation sequence was developed for the synthesis of orthogonally functionalized 2° nitroalkanes. The latter method provides rapid access to the indolizidine core.