1393718-90-5

Basic information

• Product Name: methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate
• Synonyms: methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate
• CAS NO: 1393718-90-5
• Molecular Weight: 315.316
• Mol File: 1393718-90-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate(1393718-90-5)
• EPA Substance Registry System: methyl 3-amino-4-methyl-5-(2-trifluoromethylphenyl)-thiophene-2-carboxylate(1393718-90-5)

Safety Data

• Hazardous Substances Data: 1393718-90-5(Hazardous Substances Data)

Upstream product

• 392-83-6 o-trifluoromethylphenyl bromide 
• 85006-31-1 3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester 

Relevant articles and documents

Palladium-catalyzed direct arylation using free NH2 substituted thiophene derivatives with inhibition of amination type reaction

The palladium-catalyzed direct arylation at C2 or C5 of free NH2 substituted thiophene derivatives was found to proceed in moderate to high yields using a variety of aryl halides. The choice of potassium acetate as the base was found to be crucial to inhibit the amination reaction and to promote the direct arylation.