1393746-68-3

Basic information

• Product Name: C₂₃H₂₉N₃O₃
• Synonyms: C₂₃H₂₉N₃O₃
• CAS NO: 1393746-68-3
• Molecular Weight: 395.502
• Mol File: 1393746-68-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₉N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₉N₃O₃(1393746-68-3)
• EPA Substance Registry System: C₂₃H₂₉N₃O₃(1393746-68-3)

Safety Data

• Hazardous Substances Data: 1393746-68-3(Hazardous Substances Data)

Upstream product

• 2374-03-0 4-aminosalicylic acid 
• 13452-14-7 2-methyl-6-benzoxazole carboxylic acid 

Relevant articles and documents

Benzoxazole and benzothiazole amides as novel pharmacokinetic enhancers of HIV protease inhibitors

A new class of benzoxazole and benzothiazole amide derivatives exhibiting potent CYP3A4 inhibiting properties was identified. Extensive lead optimization was aimed at improving the CYP3A4 inhibitory properties as well as overall ADME profile of these amide derivatives. This led to the identification of thiazol-5-ylmethyl (2S,3R)-4-(2-(ethyl(methyl)amino)-N-isobutylbenzo[d]oxazole- 6-carboxamido)-3-hydroxy-1-phenylbutan-2-ylcarbamate (C1) as a lead candidate for this class. This compound together with structurally similar analogues demonstrated excellent 'boosting' properties when tested in dogs. These findings warrant further evaluation of their properties in an effort to identify valuable alternatives to Ritonavir as pharmacokinetic enhancers.