1393809-08-9Relevant academic research and scientific papers
The stereoselective synthesis of cis-/trans-fused hexahydropyrano[4,3-b] chromenes via Prins cyclization trapping by a tethered nucleophile
Subba Reddy,Jalal, Sayed,Borkar, Prashant,Yadav,Reddy,Kunwar,Sridhar
, p. 6562 - 6568 (2012)
A novel intramolecular Prins cyclization of (Z)-2-(5-hydroxypent-2-enyl) phenol with various aldehydes has been achieved using 10 mol% In(OTf) 3 and 30 mol% TsOH to produce the cis-fused hexahydropyrano[4,3-b] chromene derivatives in good yields, while the coupling of (E)-2-(5-hydroxypent- 2-enyl)phenol with aldehydes under similar conditions affords the corresponding trans-fused hexahydropyrano[4,3-b]chromene derivatives.
