1393824-66-2

Upstream product

• 2251-76-5 2-(4-fluorophenyl)-2-oxoacetic acid 
• 222415-34-1 N-(2H-chromen-4-yl)acetamide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 24541-01-3 chroman-4-one oxime 

Relevant academic research and scientific papers

Decarboxylative acylation of cyclic enamides with α-oxocarboxylic acids by palladium-catalyzed C-H activation at room temperature

An efficient catalytic decarboxylative acylation of unactivated sp 2 (alkenyl) C-H bonds has been developed. Various substituted α-oxocarboxylic acids with different electronic properties react under mild conditions to afford a diverse range of β-acyl enamide products in good yields. The reaction is proposed to proceed via a cyclic vinylpalladium intermediate, facilitating the decarboxylative dehydrogenative process with enamide coupling partners.