1393911-96-0Relevant articles and documents
One-pot synthesis of thieno [2,3-d] pyrimidin-4-ol derivatives mediated by polyphosphonic anhydride
Poojari, Subba,Parameswar Naik,Krishnamurthy
experimental part, p. 4639 - 4643 (2012/09/05)
An efficient synthesis of thiopyrimidines with different substituents in position 2 is described. A rapid, mild and high yielding microwave-assisted one-pot cyclization of 5-substituted 2-amino thiophene-3-carboxamide derived from Gewald reaction1 with T3P and different acids gives the corresponding thiopyrimidines. The significant feature of this method includes less reaction time, high purity and reduced toxicity of the reaction.