1393933-89-5

Basic information

• Product Name: C₃₉H₆₂N₁₀O₁₅S
• Synonyms: C₃₉H₆₂N₁₀O₁₅S
• CAS NO: 1393933-89-5
• Molecular Weight: 943.045
• Mol File: 1393933-89-5.mol

Chemical Properties

• CAS DataBase Reference: C₃₉H₆₂N₁₀O₁₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₉H₆₂N₁₀O₁₅S(1393933-89-5)
• EPA Substance Registry System: C₃₉H₆₂N₁₀O₁₅S(1393933-89-5)

Safety Data

• Hazardous Substances Data: 1393933-89-5(Hazardous Substances Data)

Upstream product

• 1190101-34-8 4-(4,7-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7-triazacyclononane-1-yl)-5-(tert-butoxy)-5-oxopentanoic acid 
• 1345512-10-8 4-(4,7-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7-triazacyclononan-1-yl)-5-(tert-butoxy)-5-oxopentanoic acid NHS ester 
• 1393933-97-5 C₅₁H₈₆N₁₀O₁₅S 

Relevant articles and documents

Synthesis and characterization of αvβ3- targeting peptidomimetic chelate conjugates for PET and SPECT imaging

There is growing interest in small peptidomimetic αvβ 3 integrin antagonists that are readily synthesized and characterized and can be easily handled using physiological conditions. Peptidomimetic 4-[2-(3,4,5,6-tetrahydropyrimidine-2-ylamino)ethyloxy]benzoyl-2-[N-(3-amino- neopenta-1-carbamyl)]-aminoethylsulfonyl-amino-β-alanine (IAC) was successfully conjugated to 1-(1-carboxy-3-carbo-t-butoxypropyl)-4,7-(carbo-tert- butoxymethyl)-1,4,7-triazacyclononane (NODA-GA(tBu)3) and 1-(1-carboxy-3-carbotertbutoxymethyl)-1,4,7,10-tetraazacyclododecane (DOTA-GA(tBu)4) and radiolabeled with 111In, 67Ga and 203Pb. Results of a radioimmunoassay demonstrated binding to purified αvβ3 integrin when 1-4 equiv of integrin were added to the reaction. Based on this promising result, investigations are moving forward to evaluate the NODA-GA-IAC and DOTA-GA-IAC conjugates for targeting tumor associated angiogenesis and α vβ3 integrin positive tumors to define their PET and SPECT imaging qualities as well as their potential for delivery of therapeutic radionuclides.