1393953-80-4

Basic information

• Product Name: 2-(3,4-dimethoxyphenyl)-5-methoxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one
• Synonyms: 2-(3,4-dimethoxyphenyl)-5-methoxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one
• CAS NO: 1393953-80-4
• Molecular Weight: 432.427
• Mol File: 1393953-80-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dimethoxyphenyl)-5-methoxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethoxyphenyl)-5-methoxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one(1393953-80-4)
• EPA Substance Registry System: 2-(3,4-dimethoxyphenyl)-5-methoxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one(1393953-80-4)

Safety Data

• Hazardous Substances Data: 1393953-80-4(Hazardous Substances Data)

Upstream product

• 1197215-50-1 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-bis(methoxymethoxy)-4H-chromen-4-one 
• 74-88-4 methyl iodide 

Downstream Products

• 3306-16-9 2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-5-methoxy-4H-chromen-4-one 

Relevant articles and documents

Metabolism-based synthesis, biologic evaluation and SARs analysis of O-methylated analogs of quercetin as thrombin inhibitors

In blood, quercetin is mainly found in metabolized forms. In order to study the activities of these quercetin metabolites in cardiovascular disease, 17 methylquercetin derivatives were synthesized based on metabolism in vivo, their thrombin inhibition activity were evaluated through the analyzation of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB). The results showed that 6 methylquercetin derivatives had stronger inhibitory activities than that of quercetin. Preliminary SARs analysis showed that hydroxyl groups at C-3′ and C-4′ position in the B-ring and hydroxyl group at C-3 position in the C-ring played key roles in the thrombin inhibitory activity. The findings of this study would provide information for the exploitation and utilization of quercetin as thrombin inhibitor for thrombotic disease treatment.