139402-21-4Relevant articles and documents
Synthesis of (+)-aptosimon, a 4-oxofurofuran lignan, by erythro selective aldol condensation and stereoconvergent cyclization as the key reactions
Yamauchi, Satoshi,Yamaguchi, Munetoshi
, p. 838 - 846 (2007/10/03)
The 4-oxofurofuran lignan, (+)-aptosimon (1), was synthesized from γ-butyrolactone (9). To construct the two benzylic chiral center of (+)-aptosimon (1), highly erythro selective aldol condensation and stereoconvergent SN1 intramolecular cyclization were used as the key reactions.
Synthesis of endo,exo-furofuranones using a highly diastereoselective C-H insertion reaction
Brown, Richard C.D.,Hinks, Jeremy D.
, p. 1895 - 1896 (2007/10/03)
A highly stereoselective ring closure of α-diazo-γ-butyrolactones to form the 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane ring system is reported; a formal synthesis of the furofuran lignan asarinin 1 is also described.
Synthetic methods for (Exo,Exo)- and (Exo-,Endo)-2,6-diarylbicyclo[3:3:0]octane lignans: Syntheses of (±)-aptosimon, (±)-styraxin, (±)-asarinin, and (±)-pluviatilol
Stevens,Whiting
, p. 4629 - 4632 (2007/10/02)
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