139404-58-3Relevant academic research and scientific papers
Chiral Synthesis via Organoboranes. 34. Selective Reductions. 47. Asymmetric Reduction of Hindered α,β-Acetylenic Ketones with B-Chlorodiisopinocampheylborane to Propargylic Alcohols of Very High Enantiomeric Excess. Improved Workup Procedure for the Isol
Ramachandran, P. Veeraraghavan,Teodorovic, Aleksandar V.,Rangaishenvi, Milind V.,Brown, Herbert C.
, p. 2379 - 2386 (2007/10/02)
The Midland reagent, Alpine-Borane (2a), is excellent for the asymmetric reduction of many acetylenic ketones but it fails with hindered derivatives.On the other hand, B-chlorodiisopinocampheylborane (DIP-Chloride, 4) reacts with hindered α,β-acetylenic k
