1394124-22-1Relevant articles and documents
Synthesis and antifungal activities of new type β-methoxyacrylate- based strobilurin analogues
Zhang, Xiang,Liu, Huijun,Gao, Yongxin,Wang, Huili,Guo, Baoyuan,Li, Jianzhong
experimental part, p. 1517 - 1524 (2012/09/07)
Strobilurins have become one of the most important classes of agricultural fungicides. To discover new strobilurin derivatives with high activity against resistant pathogens, a series of novel β-methoxyacrylate analogues were designed and synthesized by integrating substituted pyrimidine with a strobilurin pharmacophore. The compounds were confirmed and characterized by infrared, 1H nuclear magnetic resonance, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activity against Colletotrichum orbiculare, Botrytis cinerea Pers and Phytophthora capsici Leonian at the concentration of 50 μg/mL. Exhilaratingly, compound 1a (R=methyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin. Copyright