1394128-71-2

Upstream product

• 1394128-62-1 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-thiadiazole 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1394128-59-6 2-(phenylaminosulfonylmethyl)-5-[E-(2-phenylsulfonylvinylsulfonylmethyl)]-1,3,4-oxadiazole 
• 1370346-30-7 C₈H₁₁N₃O₃S 

Relevant academic research and scientific papers

Synthesis, antimicrobial and cytotoxic activities of sulfone linked bis heterocycles

A new class of sulfone linked bis heterocycles viz., pyrrolyl/pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, and 1,2,4-triazoles were prepared and tested for antimicrobial activity and cytotoxicity. The chloro-substituted compounds 5c, 8c and 14c showed comparable antibacterial activity to chloramphenicol against Pseudomonasaeruginosa and compound 5c exhibited comparable antifungal activity to ketoconazole against Penicilliumchrysogenum. One of the compounds, vinylsulfonyl oxadiazole showed appreciably cytotoxic activity on A549 lung carcinoma cells with an IC 50 at a concentration of 31.7 μM.