1394166-08-5

Basic information

• Product Name: (Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one
• CAS NO: 1394166-08-5
• Molecular Weight: 342.779
• Mol File: 1394166-08-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one(1394166-08-5)
• EPA Substance Registry System: (Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one(1394166-08-5)

Safety Data

• Hazardous Substances Data: 1394166-08-5(Hazardous Substances Data)

Upstream product

• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Downstream Products

• 1394165-16-2 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(2-chlorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1436418-02-8 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(2-(trifluoromethyl)phenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-23-1 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3-fluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-20-8 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(3-(trifluoromethyl)phenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-24-2 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(4-chlorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-17-3 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(4-bromophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-41-3 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(2,4-dichlorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-43-5 N-(3-fluoro-4-((6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(2,6-dichlorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1436418-50-6 1-(2,4-dimethylphenyl)-N-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1394165-28-6 N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(2-fluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1436418-03-9 1-(2-bromophenyl)-N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1436418-04-0 N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1-(3-(trifluoromethyl)phenyl)-1,4-dihydrocinnoline-3-carboxamide 
• 1436418-05-1 N-(3-fluoro-4-((6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxamide 
• 1436418-06-2 N-(3-fluoro-4-(6-methoxy-7-(3-(4-methylpiperidin-1-yl)propoxy)quinolin-4-yloxy)phenyl)-4-oxo-1-p-tolyl-1,4-dihydrocinnoline-3-carboxamide 

Relevant articles and documents

Quinoxalinone-containing 4-phenoxy substituted quinoline compound and application thereof

The invention relates to quinoxalinone-containing 4-phenoxy substituted quinoline derivatives shown as a general formula I and pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, wherein the substituent groups Ar, R1, R2 and n have meanings as shown in the description. The invention further relates to a compound with the general formula I having a strong effect of inhibitingc-Met kinase, and further relates to application of the compounds and pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof in preparation of medicines for treating and/or preventing diseases caused by abnormal high expression of the c-Met kinase, particularly application in preparation of medicines for treating and/or preventing cancers.

Dihydropyridazinone containing quinoline compound and use thereof

The invention relates to a dihydropyridazinone containing quinoline derivative shown as general formula I and its pharmaceutically acceptable salt, solvate or prodrug. Specifically, the substituents AR, R1, R2, R3, X, Y and n have the meaning given in the specification. The invention also relates to the strong c-Met kinase inhibition effect of the compound shown as the general formula I, and also relates to use of the compound and its pharmaceutically acceptable salt, solvate or prodrug in preparation of drugs treating and/or preventing diseases caused by c-Met kinase abnormal high expression, especially the use in preparation of drugs treating and/or preventing cancers. (formula I).

Quinoline compound and its preparation method and application (by machine translation)

The invention relates to the general formula I shown quinoline derivatives and their pharmaceutically acceptable salt, hydrate, solvate and prodrug, wherein substituent R1 , R2 , X, Y, Z, n has the meaning given in the specification. The invention also relates to the compounds of the general formula I has strong inhibition of c - Met kinase function, and also relates to the compounds and its pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof in the preparation of the treatment because the c - Met kinase abnormal high expression of diseases caused by the use of the medicaments, in particular in preparing and treating and/or preventing cancer of the use of the medicament. (by machine translation)