1394166-98-3Relevant academic research and scientific papers
Synthesis and Molecular Editing of Callyspongiolide, Part 1: The Alkyne Metathesis/trans-Reduction Strategy
Mata, Guillaume,W?lfl, Bernhard,Fürstner, Alois
, p. 246 - 254 (2019)
A path-scouting investigation into the highly cytotoxic marine macrolide callyspongiolide is reported that capitalizes on the selective formation of the C10?C11 alkene site. While the closure of the macrocycle by ring closing alkyne metathesis (RCAM) with
Syn-β-hydroxyallylic silanes from terminal epoxide α-lithiation-silylation and alkenylation: Application to the tetrahydrofuran portion of the lytophilippines
Hodgson, David M.,Salik, Saifullah
supporting information, p. 4402 - 4405 (2012/11/06)
Lithiation-in situ silylation of terminal epoxides using lithium 2,2,6,6-tetramethylpiperidide in combination with phenyldimethyl(or diethyl)silyl chloride provides a direct process for the synthesis of trans-α,β-epoxysilanes, which undergo α-ring opening with alkenylcoppers to give syn-β-hydroxyallylic silanes. The chemistry is applied in an annulation approach to the C10-C19 tetrahydrofuran-containing portion of the lytophilippines.
