1394172-80-5

Basic information

• Product Name: C₁₂H₁₄N₂O
• Synonyms: C₁₂H₁₄N₂O
• CAS NO: 1394172-80-5
• Molecular Weight: 202.256
• Mol File: 1394172-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₄N₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₄N₂O(1394172-80-5)
• EPA Substance Registry System: C₁₂H₁₄N₂O(1394172-80-5)

Safety Data

• Hazardous Substances Data: 1394172-80-5(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 3008-43-3 3-methylcyclohexane-1,2-dione 
• 1394172-84-9 C₁₃H₁₆N₂O 
• 1394172-79-2 5-methyl-2-(pyridin-2-ylamino)cyclopent-2-enone 

Downstream Products

• 1394173-00-2 C₁₇H₂₆N₂OSi 
• 1394173-01-3 C₁₈H₂₆N₂O 
• 1607855-31-1 C₂₃H₃₂N₂O₃ 
• 1607855-23-1 tert-butyl (E)-(2-(3,3-dimethylbut-1-en-1-yl)-5-methyl-6-oxocyclohex-1-en-1-yl)carbamate 
• 1607855-08-2 (E)-3-(3,3-dimethylbut-1-en-1-yl)-6-methyl-2-(pyridin-2-ylamino)cyclohex-2-en-1-one 
• 1607855-09-3 (E)-3-(3-((tert-butyldimethylsilyl)oxy)-3-methylbut-1-en-1-yl)-6-2-(pyridin-2-ylamino)cyclohex-2-en-1-one 

Relevant articles and documents

Catalytic intermolecular C-alkylation of 1,2-diketones with simple olefins: A recyclable directing group strategy

We describe the first example of Rh-catalyzed intermolecular C-alkylation of cyclic 1,2-diketones using simple terminal olefins as alkylating agents. Aminopyridine is employed as a recyclable directing group. First, it reacts with ketones to give enamines and delivers Rh to activate the vinyl C-H bonds in the same pot; second, it can be cleaved off and recovered via hydrolysis. A broad range of olefins can be utilized as substrates, including aliphatic, aromatic olefins and vinyl esters. The efficiency of this method is also demonstrated in the synthesis of a natural flavoring compound, 3-ethyl-5-methyl-1,2- cyclopentadione (one-pot 53% yield vs a previous four-step route 16% yield from the same starting material). This work is expected to serve as a seminal study toward catalytic ketone α-alkylation with unactivated olefins.