139436-64-9Relevant academic research and scientific papers
A catalyst free, one pot approach for the synthesis of quinoxaline derivatives via oxidative cyclisation of 1,2-diamines and phenacyl bromides
Kumar, Kapil,Mudshinge, Sagar Ravso,Goyal, Sandeep,Gangar, Mukesh,Nair, Vipin A.
supporting information, p. 1266 - 1271 (2015/03/04)
A simple, efficient and eco-friendly method has been developed for quinoxaline synthesis from inexpensive and readily available diamines and phenacyl bromides by catalyst- and additive-free protocol.
Regioselective Suzuki-Miyaura cross-coupling reactions of 2,6-dichloroquinoxaline
Ali, Iftikhar,Siyo, Baraa,Al-Soud, Yaseen,Villinger, Alexander,Langer, Peter
experimental part, p. 1637 - 1646 (2012/06/30)
A variety of mono- and diarylated quinoxaline derivatives were prepared by site-selective Suzuki-Miyaura cross-coupling reactions of 2,6- dichloroquinoxaline. The selectivity is controlled by electronic parameters. Georg Thieme Verlag Stuttgart · New York
Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor
Martin, Laetitia J.,Marzinzik, Andreas L.,Ley, Steven V.,Baxendale, Ian R.
supporting information; experimental part, p. 320 - 323 (2011/03/23)
A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator's exposure to carcinogenic phenylenediamines.
A convenient approach to the synthesis of quinoxalines from isoxazolones and 1,2-diaminobenzenes
Rao, M Hanmantha,Reddy, A Pandu Ranga,Veeranagaiah, V
, p. 88 - 91 (2007/10/02)
2-Aryl-6,7-(un)substituted-quinoxalines (3a-t) and 2-arylbenzimidazoles (4a-t) have been obtained by condensation of 3-aryl-5(4H)-isoxazolones (1a-e) and 4-(un)substituted-1,2-diaminobenzenes (2a-d) under neutral conditions.The mechanism of their formation is illustrated.
