139437-49-3

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 56613-80-0 D-2-phenylglycinol 

Downstream Products

• 139437-61-9 (R)-2-Phenyl-2-((R)-1-thiophen-3-yl-ethylamino)-ethanol 
• 139437-65-3 (R)-2-[Methyl-((R)-1-thiophen-3-yl-ethyl)-amino]-2-phenyl-ethanol 
• 139437-69-7 (R)-2-[Methyl-((S)-1-thiophen-3-yl-ethyl)-amino]-2-phenyl-ethanol 

Relevant academic research and scientific papers

Chemoselective and stereoselective synthesis of gem-difluoro-β-aminoesters or gem-difluoro-β-lactams from ethylbromodifluoroacetate and imines during Reformatsky reaction

The chemoselective and stereoselective synthesis of gem-difluoro-β-aminoesters or gem-difluoro-β-lactams was investigated from ethylbromodifluoroacetate and imines during Reformatsky reaction. Influence of various reaction parameters, such as nature of the amine part, nature of the chiral auxiliary, was evaluated. High levels of stereoselectivity (up to 98%) were obtained for gem-difluoro-β-aminoesters and gem-difluoro-β-lactams using either (R)-phenylglycinol or (R)-methoxyphenylglycinol.

DIASTEREOSELECTIVE ADDITION OF ORGANOMETALLIC REAGENTS TO CHIRAL IMINES AND 1,3-OXAZOLIDINES

The reaction of MeLi or MeMgBr with chiral aromatic imines and 2-aryl-1,3-oxazolidines derived from (R)-phenylglycinol afforded with good diastereoselectivity (R,R)-amines from imines, but the (R,S)-amines from 1,3-oxazolidines, respectively.