1394374-15-2

Upstream product

• 1394373-18-2 6-chloro-5-iodo-2-(methylsulfonyl)-1H-imidazo[4,5-b]pyridine 
• 1394373-25-1 6-chloro-5-iodo-1,3-dihydro-2H-imidazo [4,5-b] pyridine-2-thione 
• 1394373-23-9 5-chloro-6-iodopyridine-2,3-diamine 
• 1394373-21-7 5-chloro-6-iodo-3-nitropyridin-2-amine 
• 203794-33-6 2-amino-5,6-dichloro-3-nitropyridine 
• 5409-39-2 2-amino-5-chloro-3-nitropyridine 

Downstream Products

• 1394374-31-2 tert-butyl 4-((4-(2-(((3R,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)hexahydrofuro[3,2-b]furan-3-yl)oxy)-6-chloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-b]pyridin-5-yl)phenyl)ethynyl)piperidine-1-carboxylate 
• 1394374-18-5 2-(((3R,3aR,6R,6aS)-6-((tert-butyldimethylsilyl)oxy)hexahydrofuro[3,2-b]furan-3-yl)oxy)-6-chloro-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-b]pyridine 

Relevant academic research and scientific papers

NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS

Novel compounds of structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.