13944-75-7

Upstream product

• 36616-60-1 (1R,4R,6R)-4-isopropenyl-1-methyl-7-oxabicyclo[4.1.0]heptan-2-one 
• 6485-40-1 (R)-Carvone 

Downstream Products

• 57429-67-1 3,5-dinitrobenzoate ester of (+)-trans-carveol 
• 1154606-95-7 tert-butyl{[(1R,2R,4R,6R)-4-isopropenyl-1-methyl-7-oxabicyclo[4.1.0]hept-2-yl]oxy}diphenylsilane 
• 191410-13-6 1-((1R,3S,5R,6S)-5-Hydroxy-6-methyl-7-oxa-bicyclo[4.1.0]hept-3-yl)-ethanone 

Relevant academic research and scientific papers

VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING

The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

(R)-Carvone as chiral template for the synthesis of some polyols

Some (4S,6R,7R) 4,6,7-trihydroxyheptyl derived building blocks have been obtained from (R)-carvone as the chiral template.A key-step is the Baeyer-Villiger oxidation of a suitable intermediate.

Synthesis of the four epimeric tosylates of (5R)-2,3-epoxy-5-isopropenyl-cyclohexanol

Described is the synthesis of the four optically pure epoxytosylates 5, 6, 9 and 12, each with four chiral centers determined, from a single starting material, (R)(-) carvone.

Efficient Enantiospecific Synthesis of Key A-Ring Synthons for the Preparation of 1α,25-Dihydroxyvitamin D3 Using a Chromium((II)-Mediated Reaction

Key A-ring synthons for the synthesis of 1α,25-dihydroxyvitamin D3 have been prepared efficiently from (R)-(-)-carvone by use of diastereoselective chromium(II)-mediated addition of an allylic halide to an aldehyde as a key step.