139461-72-6Relevant articles and documents
Therapeutic uses of tri-aryl acid derivatives
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Page/Page column 171, (2010/10/20)
The use of triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.
Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids
Lin, Jun,Liao, Subo,Hruby, Victor J.
, p. 3117 - 3120 (2007/10/03)
Four conformationally constrained, highly hydrophobic, and enantiomerically pure chimeric aromatic amino acids have been asymmetrically synthesized in 7 steps with overall yields of 20-30%.
A practical synthesis of (R)-(-)-phenylephrine hydrochloride
Gurjar, Mukund K.,Krishna, L. Murali,Sarma, Bugga V.N.,Chorghade, Mukund S.
supporting information, p. 422 - 424 (2013/09/08)
(R)-(-)-Phenylephrine hydrochloride is a clinically potent adrenergic agent and β-receptor sympathomimetic drug, exclusively marketed in the optically active form. An asymmetric synthesis has been developed with high enantiomeric excess based on hydrolytic kinetic resolution of a styrene oxide derivative using (R,R)-SalenCoIIIOAc complex.
