13948-35-1Relevant academic research and scientific papers
Preparation of tertiary amines from nitriles and secondary amines
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, (2008/06/13)
A process for preparing amines of the general formula (I) where R1 and R2 are preferably methyl, X is preferably 1,4-butylene and n is preferably 2, comprises reacting nitriles of the general formula (II) where R1, R2 and X are each as defined above and m is an integer from 1 to n, with secondary amines of the general formula (III) where R1 and R2 are each as defined above, and hydrogen at from 50 to 250° C. and from 5 to 350 bar in the presence of a palladium catalyst comprising, based on the total weight of the catalyst, from 0.1 to 10% by weight of Pd and from 0.01 to 10% by weight of at least one further metal selected from groups IB and VII of the Periodic Table, cerium and lanthanum on a support.
