139481-41-7

Basic information

• Product Name: Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate
• Synonyms: Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate;CANDESARTAN C;1H-Benzimidazole-7-carboxylicacid-1-[(2′cyano[1,1′- biphenyl]-4-yl)methyl]-2-ethoxy-ethylester;Ethyl 2-ethoxy-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole-7-carboxylate;H-Benzimidazole-7-Carboxylicacid,1-[(2'-cyano[1.1'biphenyl]-4-yl)methyl]-2-ethoxy-ethylester;Ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylate;[4-(2-cyanophenyl)phenyl]Methyl 2-ethoxy-1-ethyl-1H-1,3-benzodiazole-7-carboxylate;Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] BenziMidazole]-7-Carboxylate,C6
• CAS NO: 139481-41-7
• Molecular Formula: C₂₆H₂₃N₃O₃
• Molecular Weight: 425.486
• EINECS: 1806241-263-5
• Product Categories: Chemical intermediate for Candesartane
• Mol File: 139481-41-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 637.542 °C at 760 mmHg
• Flash Point: 339.374 °C
• Appearance: /
• Density: 1.19
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.20±0.10(Predicted)
• CAS DataBase Reference: Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate(139481-41-7)
• EPA Substance Registry System: Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate(139481-41-7)

Safety Data

• Hazardous Substances Data: 139481-41-7(Hazardous Substances Data)

Usage

General Description

Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate is a chemical compound with a complex structure. It consists of an ethyl and an ethoxy group, as well as a benzimidazole and a cyanobiphenyl group. The compound also contains a carboxylate functional group. It is used in research and development for its potential pharmaceutical or biological activity, however, further detailed studies are required to fully understand its properties and potential applications.

Upstream product

• 61063-11-4 2-Amino-3-nitrobenzoic acid,ethyl ester 
• 136285-66-0 3-nitro-phthalic acid-1-ethyl ester-2-chloride 
• 16533-45-2 ethyl 2-carboxy-3-nitrobenzoate 
• 78-09-1 orthocarbonic acid tetraethyl ester 
• 136285-69-3 ethyl 3-amino-2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>benzoate 
• 136285-67-1 ethyl 2-[(2'-cyanobiphenyl-4-yl)methyl]amino-3-nitrobenzoate 

Downstream Products

• 139481-59-7 candesartan 
• 139481-72-4 2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid 
• 1403474-75-8 ethyl 2-ethoxy-1-((2'-(N'-((ethoxycarbonyl)oxy)carbamimidoyl)[biphenyl]-4-yl)methyl)-1H-benzoimidazole-7-carboxylate 
• 1397836-41-7 ethyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 1397836-41-7 2-ethoxy-3-[[2'-(N-hydroxycarbamimidoyl)biphenyl-4-yl]methyl]benzimidazole-4-carboxylic acid ethyl ester 
• 1397836-52-0 ethyl 3-((2'-cyanobiphenyl-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate 
• 1417576-01-2 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2′-(4-ethyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate 
• 1417576-00-1 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-oxo-3-((2’-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1’-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate 
• 863031-21-4 Azilsartan medoxomil 
• 147403-03-0 azilsartan 
• 1403474-70-3 ethyl ester of 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylic acid 
• 147403-52-9 methyl 2-ethoxy-1-((2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methyl)-1H-benzo[d]-imidazole-7-carboxylate 
• 139481-33-7 methyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2,3-dihydro-2-oxo-1H-benzimidazole-7-carboxylate 
• 139481-58-6 ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate 

Relevant articles and documents

Synthesis, characterization of benzimidazole carboxamide derivatives as potent anaplastic lymphoma kinase inhibitor and antioxidant activity

Novel benzimidazole carboxamide derivatives have been synthesized and characterized by FTIR, NMR, and mass spectral analysis. The synthesized compounds 7a, 7d, and 7f showed excellent scavenging capacity against DPPH radical and the results are comparable with ascorbic acid. In-silico molecular docking studies exhibited compounds 7a, 7d, and 7f had a good affinity towards the active pocket and the results indicated the ability of potent and selective inhibition of anaplastic lymphoma kinase (ALK) receptor. The theoretical investigation of MEPs, HOMO, LUMO, and the energy gap of HOMO-LUMO were calculated by B3LYP/6-31G method and reactivity descriptors were also computed.