1394820-69-9 Usage
Uses
Ningetinib, is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively.
Check Digit Verification of cas no
The CAS Registry Mumber 1394820-69-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,4,8,2 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1394820-69:
(9*1)+(8*3)+(7*9)+(6*4)+(5*8)+(4*2)+(3*0)+(2*6)+(1*9)=189
189 % 10 = 9
So 1394820-69-9 is a valid CAS Registry Number.
1394820-69-9Relevant articles and documents
SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE
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, (2012/09/10)
The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.