1394848-48-6Relevant articles and documents
Efficient synthesis of 2′-C-α-aminomethyl-2′- deoxynucleosides
Li, Nan-Sheng,Piccirilli, Joseph A.
, p. 8754 - 8756 (2012/10/08)
Starting from methyl 3,5-di-O-benzyl-2-keto-α-d-ribofuranoside, a convergent, six-step synthesis is developed to give efficiently all four 2′-C-α-aminomethyl-2′-deoxynucleosides (U, C, A, G) in 38%, 42%, 12%, 12% yield, respectively. Convergence is achieved by the glycosylation of persilylated nucleobases with methyl 2-α-phthalimidomethyl ribofuranoside.