1394854-75-1

Basic information

• Product Name: (S)-N-(3-aminopropyl)-2-pipecoline
• Synonyms: (S)-N-(3-aminopropyl)-2-pipecoline
• CAS NO: 1394854-75-1
• Molecular Weight: 156.271
• Mol File: 1394854-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-(3-aminopropyl)-2-pipecoline(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(3-aminopropyl)-2-pipecoline(1394854-75-1)
• EPA Substance Registry System: (S)-N-(3-aminopropyl)-2-pipecoline(1394854-75-1)

Safety Data

• Hazardous Substances Data: 1394854-75-1(Hazardous Substances Data)

Upstream product

• 1394854-73-9 (S)-N-(3-(2-pipecolin-1-yl)propyl)phthalimide 

Downstream Products

• 1394847-65-4 (S)-4-((3-(2-methylpiperidin-1-yl)propylamino)methyl)benzaldehyde 
• 1394847-39-2 3-((R)-2-methylpiperidin-1-yl)-N-(4-((3-((S)-2-methylpiperidin-1-yl)propylamino)methyl)benzyl)propan-1-amine 
• 1394847-29-0 (S)-N,N'-(1,4-phenylenebis(methylene))bis(3-((S)-2-methylpiperidin-1-yl)propan-1-amine) 
• 1394847-62-1 (S)-N-(4-(diethoxymethyl)benzyl)-3-(2-methylpiperidin-1-yl)propan-1-amine 

Relevant articles and documents

Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells

The three stereoisomers of the noncyclam compound 1 (1(R,R), 1(S,S), and the meso form 1(S,R)) and their corresponding tetrahydrochlorides 11 were prepared from (S)- and (R)-2-methylpiperidine. We have evaluated their inhibitory activity on the CXC chemokine receptor type 4 (CXCR4), toxicity properties, and assessment of their effect on glioma initiating cells (GICs) in comparison with the prototype compound AMD3100. The IC50 values determined on human recombinant (CHO) cells showed very similar inhibitory activities albeit a lower KB for AMD3100, with the 1(R,R) isomer being second in potency. All the compounds showed low cardiac toxicity but, contrary to AMD3100, gave maximum nonlethal doses of around 2.0 mg/kg. The CXCR4 inhibitors had an effect on the state of differentiation of GICs, decreasing the percentage of CD44+ cells in glioblastoma multiform neurospheres in vitro. Moreover, these CXCR4 inhibitors blocked the capacity of cells to initiate orthotopic tumors in immunocompromised mice.