1394897-19-8

Basic information

• Product Name: C₃₄H₅₇NO₅
• Synonyms: C₃₄H₅₇NO₅
• CAS NO: 1394897-19-8
• Molecular Weight: 559.83
• Mol File: 1394897-19-8.mol

Chemical Properties

• CAS DataBase Reference: C₃₄H₅₇NO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₅₇NO₅(1394897-19-8)
• EPA Substance Registry System: C₃₄H₅₇NO₅(1394897-19-8)

Safety Data

• Hazardous Substances Data: 1394897-19-8(Hazardous Substances Data)

Upstream product

• 765-13-9 pentadec-1-yne 
• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 115464-01-2 (4S,1'R)-4-(1'-Hydroxy-2'-hexadecinyl)-2,2-dimethyl-3-oxazolidincarbonsaeure-tert-butylester 

Relevant articles and documents

Effects of chemical modification of sphingomyelin ammonium group on formation of liquid-ordered phase

Sphingomyelin (SM) and cholesterol form microdomains called lipid rafts in cellular membranes. To develop a versatile fluorescent lipid probe, chemical modifications to both the hydrophobic and hydrophilic portions of SM are essential. Few reports describing SM probes with a fluorophore at the polar head group have been published. This study examined the effect of substitution on an ammonium moiety of SM on the membrane properties of SM. Two SM analogs with small propargyl and allyl groups on the quaternary nitrogen atom were synthesized and subjected to analysis using differential scanning calorimetry, fluorescent anisotropy, detergent solubilization, surface pressure, and density measurements. Results demonstrated that the two SM analogs retained the membrane properties of SM, including formation of an ordered phase and the ability to interact with cholesterol. A dansyl-substituted SM was prepared for fluorescent measurements. Dansyl-SM showed less of a propensity to form microdomains. These findings imply the potential application of N-substituted SMs as a raft-specific molecular probe.