1394901-97-3

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 95-68-1 2,4-Xylidine 

Downstream Products

• 1394901-86-0 8-chloro-2-(2,4-dimethylphenyl)-pyrrolo[2,3,4-kl]acridin-1(2H)-one 
• 1394901-84-8 2-(2,4-dimethylphenyl)-9-fluoropyrrolo[2,3,4-kl]acridin-1(2H)-one 
• 1394901-85-9 2-(2,4-dimethylphenyl)-pyrrolo[2,3,4-kl]acridin-1(2H)-one 
• 1404088-12-5 5-(2,4-dimethylphenyl)-3-hydroxyphenanthridin-6(5H)-one 
• 1404087-92-8 N-(2,4-dimethylphenyl)-N-(3-oxocyclohex-1-enyl)benzamide 

Relevant academic research and scientific papers

Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9

A highly regiospecific synthesis of a series of indenoindoles is reported, together with X-ray studies and their activity against human prostate cancer cells PC-3 and LNCaP in vitro. The most effective compound 7,7-dimethyl-5-[(3,4-dichlorophenyl)]-(4bRS,9bRS)-dihydroxy-4b,5,6,7,8,9bhexahydro-indeno[1,2-b]indole-9,10-dione 7q reduced the viability in both cell lines in a time and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on clonogenic possibly by inhibition of MMP-9 activity. Molecular docking of 7q and 6k into MMP-9 human active site was also performed to determine the probable binding mode.