1394902-93-2Relevant academic research and scientific papers
Atroposelective heck macrocyclization: Enantioselective synthesis of bis(bibenzylic) natural products
Groh, Matthias,Meidlinger, Daniel,Bringmann, Gerhard,Speicher, Andreas
, p. 4548 - 4551 (2012/10/29)
The Heck protocol was applied for the first time to the atroposelective synthesis of macrocyclic natural products. As ring closure to bis(bibenzyls) of the isoplagiochin type leads to a configurationally stable biaryl axis in the molecule, cyclization could be conducted atroposelectively in the presence of a chiral BINAP ligand.
