1394902-98-7Relevant academic research and scientific papers
Towards the enantioselective synthesis of axially chiral cyclic bis(bibenzyls) through sulfoxide-controlled diastereoselective Suzuki coupling
Schmitz, Petra,Malter, Marcus,Lorscheider, Gregor,Schreiner, Christina,Carboni, Aude,Choppin, Sabine,Colobert, Fran?oise,Speicher, Andreas
, p. 5230 - 5237 (2016/08/02)
Natural macrocyclic bis(bibenzyls) exhibiting configurationally stable axially chiral biaryls are of high interest from a structural as well as from a synthetic point of view. An enantiopure sulfinyl auxiliary controlling an atropo-diastereoselective biar
Atroposelective heck macrocyclization: Enantioselective synthesis of bis(bibenzylic) natural products
Groh, Matthias,Meidlinger, Daniel,Bringmann, Gerhard,Speicher, Andreas
supporting information, p. 4548 - 4551 (2012/10/29)
The Heck protocol was applied for the first time to the atroposelective synthesis of macrocyclic natural products. As ring closure to bis(bibenzyls) of the isoplagiochin type leads to a configurationally stable biaryl axis in the molecule, cyclization could be conducted atroposelectively in the presence of a chiral BINAP ligand.
