1394910-95-2Relevant academic research and scientific papers
5-(5-Aryl-1,3,4-oxadiazole-2-carbonyl)furan-3-carboxylate and new cyclic C-glycoside analogues from carbohydrate precursors with MAO-B, antimicrobial and antifungal activities
El-Sadek, Mohamed Mohamed,Hassan, Seham Yassen,Abd El-Dayem, Nagwa Said,Yacout, Galila Ahmed
, p. 7010 - 7027 (2012/09/07)
Cyclization of acyclic C-glycoside derivatives 1a, b to 2a, b as the major isomers, and 4a, b as the minor isomers were carried out. The isopropylidene derivatives 3a, b were prepared, as well as the hydrazide derivative 6, which was condensed with a variety of aldehydes to give hydrazones 7a-e which were also prepared from the compounds 12a-e. Acetylation of 7a, d gave the corresponding acetyl derivatives 8a, d, respectively. In addition, the dicarbonyl compound 9 was prepared in the hydrate form, which reacted with a number of aroylhydrazines to give the corresponding bisaroylhydrazones 10a-d, which were cyclized into 1,3,4-oxadiazoles 11a-d. Furthermore, two of the prepared compounds were examined to show the ability to activate MAO-B. In addition a number of prepared compounds showed antibacterial and antiviral activities.
