139493-75-7

Upstream product

• 50651-75-7 silver dibenzylphosphate 
• 139493-74-6 2,3,6-Tri-O-acetyl-4-deoxy-α-D-lyxo hexopyranosyl chloride 
• 990-91-0 dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate 
• 286843-91-2 2,3,6-tri-O-acetyl-4-deoxy-D-lyxo-hexose 
• 125287-88-9 Methyl 2,3,6-tri-O-acetyl-4-deoxy-α-D-lyxo hexopyranoside 
• 73635-99-1 methyl 2,3-O-isopropylidene-4-deoxy-α-D-lyxo-hexopyranoside 
• 286843-90-1 C₃₄H₂₈O₉ 
• 114375-64-3 1,2,3,6-Tetra-O-acetyl-4-deoxy-α-D-lyxo-hexopyranose 
• 69088-89-7 4-deoxy-α-D-lyxo-hexopyranose 

Relevant academic research and scientific papers

The preparation of deoxy derivatives of mannose-1-phosphate and their substrate specificity towards recombinant GDP-mannose pyrophosphorylase from Salmonella enterica, group B

2-Deoxy-α-D-glucose-1-phosphate, 3-deoxy-α-D-arabino-hexose-1-phosphate, 4-deoxy-α-D-lyxo-hexose-1-phosphate, and α-D-lyxose-1-phosphate were synthesised chemically, and evaluated as substrates for a recombinant GDP-mannose pyrophosphorylase (Salmonella enterica, group B, cloned in Escherichia coli). The deoxy derivatives were all substrates for the enzyme, with slightly reduced V(max) values but significantly higher K(m) values than those recorded for the native substrate, mannose-1-phosphate. The pyrophosphorylase was used for the synthesis of GDP-mannose analogues GDP-2-deoxy-glucose and GDP-lyxose on a milligram scale. Copyright (C) 2000 Elsevier Science Ltd.

Synthesis of Some Deoxymannosyl Phosphates

3-Deoxy-α-D-arabino-hexopyranosyl-, 4-deoxy-α-D-lyxo-hexapyranosyl- and 6-deoxy-α-D-mannopyranosyl phosphates 6, 12 and 21 were synthesized by phosphorylation of the deoxygenated glycosyl chlorides 3, 9 and 18 with silver dibenzyl phosphate and subsequent