1394957-71-1 Usage
Description
(4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one is a complex organic compound characterized by its unique molecular structure and stereochemistry. It is a derivative of the oxazinone class of compounds, which are known for their diverse range of biological activities and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
(4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one is used as a potential pharmaceutical candidate for the development of novel drugs. Its unique structure and functional groups may allow it to interact with specific biological targets, making it a promising candidate for the treatment of various diseases.
Used in Chemical Synthesis:
(4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one can be employed as a key intermediate in the synthesis of more complex organic molecules. Its unique functional groups and stereochemistry make it a valuable building block for the development of new compounds with potential applications in various industries.
Used in Catalyst Development:
(4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one may be utilized in the development of new catalysts for asymmetric synthesis and other chemical reactions. Its unique structure and stereochemistry could enable the design of novel catalysts with enhanced selectivity and reactivity.
Used in Research and Development:
(4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one serves as an important research tool for studying the structure-activity relationships of oxazinone derivatives. Its synthesis and evaluation in various biological assays can provide valuable insights into the design of new compounds with improved properties and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1394957-71-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,4,9,5 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1394957-71:
(9*1)+(8*3)+(7*9)+(6*4)+(5*9)+(4*5)+(3*7)+(2*7)+(1*1)=221
221 % 10 = 1
So 1394957-71-1 is a valid CAS Registry Number.
1394957-71-1Relevant articles and documents
Concerted amidation of activated esters: Reaction path and origins of selectivity in the kinetic resolution of cyclic amines via N-heterocyclic carbenes and hydroxamic acid cocatalyzed acyl transfer
Allen, Scott E.,Hsieh, Sheng-Ying,Gutierrez, Osvaldo,Bode, Jeffrey W.,Kozlowski, Marisa C.
supporting information, p. 11783 - 11791 (2014/11/08)
The N-heterocyclic carbene and hydroxamic acid cocatalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mechanical study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic acid plays a key role in directing proton transfer from the incoming amine. This modality was found to be general in amide bond formation from a number of activated esters including those generated from HOBt and HOAt, reagents that are broadly used in peptide coupling. For the kinetic resolution, the proposed model accurately predicts the faster reacting enantiomer. A breakdown of the steric and electronic control elements shows that a gearing effect in the transition state is responsible for the observed selectivity.
Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles
Hsieh, Sheng-Ying,Binanzer, Michael,Kreituss, Imants,Bode, Jeffrey W.
supporting information, p. 8892 - 8894 (2012/11/07)
The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.
