1395050-56-2Relevant academic research and scientific papers
Pyrazolylamine Derivatives Reveal the Conformational Switching between Type i and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK)
Tu, Chih-Hsiang,Lin, Wen-Hsing,Peng, Yi-Hui,Hsu, Tsu,Wu, Jian-Sung,Chang, Chun-Yu,Lu, Cheng-Tai,Lyu, Ping-Chiang,Shih, Chuan,Jiaang, Weir-Torn,Wu, Su-Ying
, p. 3906 - 3919 (2016/05/24)
Most anaplastic lymphoma kinase (ALK) inhibitors adopt a type I binding mode, but only limited type II ALK structural studies are available. Herein, we present the structure of ALK in complex with N1-(3-4-[([5-(tert-butyl)-3-isoxazolyl]aminocarbonyl)amino
PYRAZOLE COMPOUNDS AND THIAZOLE COMPOUNDS AS PROTEIN KINASES INHIBITORS
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Paragraph 0095; 0096, (2013/03/26)
A compound of formula (I): wherein A, B, D, X, Y, R1, R2, R3, m, p, and q are defined herein. Also disclosed is a method for inhibiting FMS-like tyrosine kinase 3, aurora kinase, or vascular endothelial growth factor receptor.
