1395060-58-8Relevant articles and documents
Tandem chain extension-Mannich reaction: An approach to β-proline derivatives
Jacobine, Alexander M.,Puchlopek, Angela L.A.,Zercher, Charles K.,Briggs, Jon B.,Jasinski, Jerry P.,Butcher, Raymond J.
experimental part, p. 7799 - 7805 (2012/09/22)
A zinc carbenoid-initiated chain extension reaction provides access to an organometallic intermediate, which can be used to capture activated imines. Deprotection of the nitrogen and reduction provides access to racemic derivatives of β-proline. The relative stereochemistry of the β-proline can be controlled through use of different activating groups on the imine nitrogen.
