1395068-08-2Relevant academic research and scientific papers
Chemoselective Suzuki-Miyaura coupling of bromophenyl-substituted bromoallenes with arylboronic acids
Du, Xin,Liu, Xuesong,Xu, Liang,Jiang, Wenfeng,Bao, Ming,He, Ren
experimental part, p. 1505 - 1510 (2012/07/27)
Developing highly chemoselective Suzuki-Miyaura coupling reactions is of great value in the synthetic chemistry. Here we report the results of palladium-catalyzed reaction of bromoallenes containing an aryl bromide moiety with arylboronic acids. It is found that the C-Br insertion exclusively takes place on bromoallene rather than on the benzene ring. Theoretical calculations demonstrate that the corresponding oxidative addition intermediate has a much lower free energy. Georg Thieme Verlag Stuttgart · New York.
