139508-73-9 Usage
Uses
Depudecin is a potent inhibitor of HDAC.
Definition
ChEBI: A polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo
/ital> and in vitro and also exhibits anti-angiogenic activity.
Check Digit Verification of cas no
The CAS Registry Mumber 139508-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,5,0 and 8 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139508-73:
(8*1)+(7*3)+(6*9)+(5*5)+(4*0)+(3*8)+(2*7)+(1*3)=149
149 % 10 = 9
So 139508-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H16O4/c1-3-7(13)11-9(15-11)5-4-8-10(14-8)6(2)12/h3-13H,1H2,2H3/b5-4+/t6-,7-,8?,9+,10+,11+/m1/s1
139508-73-9Relevant articles and documents
An Olefin Cross-Metathesis Approach to Depudecin and Stereoisomeric Analogues
Cheng-Sánchez, Iván,García-Ruiz, Cristina,Guerrero-Vásquez, Guillermo A.,Sarabia, Francisco
, p. 4744 - 4757 (2017/05/12)
A new total synthesis of the natural product (?)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, which provides for an efficient and improved access to natural depudecin, compared with our previous linear synthesis. Featured by its brevity and convergency, our developed synthetic strategy was applied to the preparation of the 10-epi derivative and the enantiomer of depudecin, which represent interesting stereoisomeric analogues for structure-activity relationship studies.
