1395101-74-2Relevant academic research and scientific papers
Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function
Chauhan, Jay,Chen, Shen-En,Fenstermacher, Katherine J.,Naser-Tavakolian, Aurash,Reingewertz, Tali,Salmo, Rosene,Lee, Christian,Williams, Emori,Raje, Mithun,Sundberg, Eric,Destefano, Jeffrey J.,Freire, Ernesto,Fletcher, Steven
, p. 7095 - 7109 (2015)
Small-molecule mimetics of the β-hairpin flap of HIV-1 protease (HIV-1 PR) were designed based on a 1,4-benzodiazepine scaffold as a strategy to interfere with the flap-flap protein-protein interaction, which functions as a gated mechanism to control acce
