139517-52-5Relevant academic research and scientific papers
Discovery of a necroptosis inhibitor improving dopaminergic neuronal loss after mptp exposure in mice
Oliveira, Sara R.,Dionísio, Pedro A.,Gaspar, Maria M.,Ferreira, Maria B. T.,Rodrigues, Catarina A. B.,Pereira, Rita G.,Estev?o, Mónica S.,Perry, Maria J.,Moreira, Rui,Afonso, Carlos A. M.,Amaral, Joana D.,Rodrigues, Cecília M. P.
, (2021/05/21)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-independent f
Synthesis of enantiomerically pure β,β-diphenylalanine (Dip) and fluorenylglycine (Flg)
Royo, Soledad,Jimenez, Ana I.,Cativiela, Carlos
, p. 2393 - 2400 (2007/10/03)
A new strategy for the preparation of both enantiomers of two phenylalanine analogues, β,β-diphenylalanine and fluorenylglycine, has been developed. The combination of a high yielding racemic synthesis and a very efficient resolution procedure has provided significant amounts of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis. This methodology can be easily applied to the preparation of larger quantities of enantiopure compounds.
A MODIFICATION OF THE PLOECHL-ERLENMEYER REACTION. I. SYNTHESIS OF 2-PHENYL-4-DIPHENYLMETHYLENE-5(4H)-OXAZOLONE
Ivanova, Ginka G.
, p. 177 - 186 (2007/10/02)
An N-methylketimine has been found to be an effective reagent in the Erlenmeyer azlactone synthesis. 2-Phenyl-4-diphenylmethylene-5(4H)-oxazolone (1) has been synthesized by the reaction of 2-phenyl-5(4H)-oxazolone (A) with N-methyl-diphenylmethanimine (B
