139517-63-8

Basic information

• Product Name: L-Alanine, N-[D-2-(3-bromo-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl]glyc yl]-, methyl ester
• CAS NO: 139517-63-8
• Molecular Formula: C17H23BrN2O6
• Molecular Weight: 431.283
• Mol File: 139517-63-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Alanine, N-[D-2-(3-bromo-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl]glyc yl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[D-2-(3-bromo-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl]glyc yl]-, methyl ester(139517-63-8)
• EPA Substance Registry System: L-Alanine, N-[D-2-(3-bromo-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl]glyc yl]-, methyl ester(139517-63-8)

Safety Data

• Hazardous Substances Data: 139517-63-8(Hazardous Substances Data)

Upstream product

• 139517-61-6 (R)-3-bromo-4-hydroxyphenylglycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 139517-62-7 (2R)-2-(3-bromo-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid 

Downstream Products

• 139517-64-9 <(R)-(3-bromo-4-methoxyphenyl)-N-tert-butoxycarbonylglycyl>-(S)-alanine methyl ester 

Relevant articles and documents

Application of the Suzuki Biphenyl Synthesis to the Natural Products Biphenomycin and Vancomycin

The synthesis of the unsymmetrical biphenyls 10 and 25 has been carried out by the palladium(0) catalysed coupling of the aryl boronic derivatives 5 and 20 with the aryl bromides 9 and 23 derived from (R)-4-hydroxyphenylglycine and (S)-tyrosine.In the former case unsuccessful attempts were made to bring about cyclization to compound 4 which is an analogue of the biphenyl ring system found in vancomycin.In the latter case, a variety of cyclization methods were used to give the cyclic products 34 and 35 which are analogues of the biphenomycin antibiotics.