139517-71-8Relevant articles and documents
MACROCYCLIC FACTOR VIIA INHIBITORS
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Paragraph 00233, (2015/01/09)
The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.
Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity
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, (2008/06/13)
Disclosed are compounds of formula (I) wherein W is CH or N; R is (mono- or di cabocyclic or heterocyclic aryl)-lower alkyl; R1is hydrogen or lower alkyl; R2and R3are hydrogen, lower alkyl, lower alkoxy-lower alkyl or aryl
Application of the Suzuki Biphenyl Synthesis to the Natural Products Biphenomycin and Vancomycin
Brown, Allan G.,Crimmin, Michael J.,Edwards, Peter D.
, p. 123 - 130 (2007/10/02)
The synthesis of the unsymmetrical biphenyls 10 and 25 has been carried out by the palladium(0) catalysed coupling of the aryl boronic derivatives 5 and 20 with the aryl bromides 9 and 23 derived from (R)-4-hydroxyphenylglycine and (S)-tyrosine.In the former case unsuccessful attempts were made to bring about cyclization to compound 4 which is an analogue of the biphenyl ring system found in vancomycin.In the latter case, a variety of cyclization methods were used to give the cyclic products 34 and 35 which are analogues of the biphenomycin antibiotics.