1395322-33-4Relevant academic research and scientific papers
Preparation of aryl-substituted 2-oxyindoles by superelectrophilic chemistry
Naredla, Rajasekhar Reddy,Raja, Erum K.,Klumpp, Douglas A.
, p. 3245 - 3247 (2013)
A series of pyridyl-substituted 3-hydroxy-2-oxyindoles have been prepared and reacted with arenes in superacid promoted Friedel-Crafts reactions. The product aryl-substituted 2-oxyindoles are formed in generally good yields. With substituted arenes such as toluene, bromobenzene, or ethyl salicylate, the Friedel-Crafts reactions occur with excellent regioselectivity. A mechanism is proposed involving dicationic, superelectrophilic species leading to the electrophilic aromatic substitution chemistry.
Iodine-catalyzed efficient synthesis of azaarene substituted 3-hydroxy-2-oxindole derivatives through sp3 C-H functionalization
Vuppalapati, Srinivasu V.N.,Lee, Yong Rok
experimental part, p. 8286 - 8292 (2012/09/11)
Iodine-catalyzed benzylic sp3 C-H bond functionalization of lutidines or picolines to isatins is described. This synthetic method provides a rapid entry towards biologically interesting 3-azaarene substituted 3-hydroxy-2-oxindole derivatives.
