139536-99-5

Upstream product

• 76780-19-3 1,1′-(propane-1,3-diyl)bis(4-methylpyridinium) dibromide 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 889-36-1 (E)-4-[4-(dimethylamino)styryl]pyridine 
• 108-89-4 picoline 
• 121-69-7 N,N-dimethyl-aniline 
• 109-64-8 1,3-dibromo-propane 
• 100-61-8 N-methylaniline 

Downstream Products

• 118160-62-6 (E)-1-(3-bromopropyl)-4-(4-(dimethylamino)styryl)pyridinium bromide 

Relevant academic research and scientific papers

Rational Design of Crystallization-Induced-Emission Probes To Detect Amorphous Protein Aggregation in Live Cells

Unlike amyloid aggregates, amorphous protein aggregates with no defined structures have been challenging to target and detect in a complex cellular milieu. In this study, we rationally designed sensors of amorphous protein aggregation from aggregation-induced-emission probes (AIEgens). Utilizing dicyanoisophorone as a model AIEgen scaffold, we first sensitized the fluorescence of AIEgens to a nonpolar and viscous environment mimicking the interior of amorphous aggregated proteins. We identified a generally applicable moiety (dimethylaminophenylene) for selective binding and fluorescence enhancement. Regulation of the electron-withdrawing groups tuned the emission wavelength while retaining selective detection. Finally, we utilized the optimized probe to systematically image aggregated proteome upon proteostasis network regulation. Overall, we present a rational approach to develop amorphous protein aggregation sensors from AIEgens with controllable sensitivity, spectral coverage, and cellular performance.

Helical aggregates of bis(styryl) dyes formed by DNA templating

In order to further investigate mechanism of the styryl dye – DNA interaction, three different bis(styryl)pyridinium dyes possessing OMe or/and NMe2 substituents in phenyl ring were selected and interaction of these compounds with the calf thymus DNA (ct-DNA) was monitored by using of UV–vis and fluorescence spectroscopic techniques, circular dichroism (CD), Hoechst 33258 displacement experiments and quantum-chemical calculations. The experimental results indicated a higher fluorescence enhancement for dyes containing NMe2 group upon binding with DNA. The results proved the interaction of the molecules with ct-DNA occurs through the formation of aggregates in minor groove at high dye concentration. Bis(styryl) dye with OMe substituent forms the helical dye aggregates of right-handed chirality, whereas, dye containing NMe2 group demonstrates formation of left-handed chiral aggregates in minor groove of DNA. As the DNA concentration increases, the dyes begin to spread out along the minor groove. This research provided a better understanding of mechanism of styryl dye - DNA interaction and effect of dye structure on interacting mode with DNA.

Photophysical studies on the mono- and dichromophoric hemicyanine dyes I. Photoelectric conversion from the dye modified ITO electrodes

Stilbazolium dimers were designed and synthesized in which methylene groups of different lengths link the two chromophores. The second-order nonlinear optical property has been detected from their Langmuir-Blodgett monolayers. Photocurrent generation as well as other photophysical properties such as absorption and fluorescence were investigated. Comparing the dimers with the stilbazolium monomer, we found strong second harmonic generation (SHG) signals and remarkable enhanced photoelectric conversion (PEC) quantum yields from 1,3-Bis [(E)- 4-(2-(4-(N-methyl, N-octadecylamino) phenyl) ethenyl) pyridinyl]-alkane dibromide (B3) and 1,5-Bis [(E)- 4-(2-(4-(N-methyl, N-octadecylamino) phenyl) ethenyl) pyridinyl]-alkane dibromide (B5). The structures of the Langmuir-Blodgett films of these dyes are assumed. Although these dimers are center-symmetric (or quasi-center-symmetric) molecules, they can form the ordered non-center-symmetric (in normal direction) monolayer by the compress force and the molecular interaction between the amphiphilic dye molecules and the water molecules at the air/water interface. The influences of bias, donor/acceptor, soluble oxygen, and light intensity to photocurrent generation were studied; our results provide a new perspective to improve the performance of functional molecular material without any change of the chemical structure of the chromophore itself.

Synthesis of some bischromophoric dyes containing nonabsorbing flexible bridge

Bis-chromophoric dyes (9-68) having nonabsorbing flexible bridges have been synthesised by the condensation of 1,1'-alkylenebis (α/γ picolinium bromides) (1-8) with aromatic aldehydes.